Year : 2015

Volume : Volume 5

Issue : Issue 1

Address for correspondence :
Dr. Hima Bindu Gireddy
hima_gireddy@yahoo.co.in

Abstract

Aims: Barrier membranes used as Guided tissue regeneration (GTR) at operative site may be prone for microbial colonization. So, preoperative coating of these membranes with antibiotics like doxycycline may help to achieve better regeneration by hindering re-infection.  Materials & methods: 16 patients, 10 females (6 patients with bilateral defects & 4 patients with only one angular defect)  & 6 males (2 patients with bilateral & 2 patients with only one angular defect) aged between 25 to 55 years with the mean age of 38 years with two or three walled infra bony defects were randomly selected, divided into two groups, group A & B. Patients in group A received doxycycline coated GTR (Healiguide) membrane which was incorporated over the intrabony defect after flap surgery, whereas group B patients received only GTR(Healiguide) membrane after the surgical debridement. Microbiologic assessment of Porphyromonas gingivalis (Pg) & Prevotella intermedia(Pi) levels were done at baseline, 6 and 12 weeks. Clinical parameters like Plaque index (PI), Probing depth (PD), Clinical attachment level (CAL), and radiographic evaluation with grid were done at baseline, 3 & 9 month intervals.  Results: There was a statistically significant reduction in, Pg levels (p<0.001), Pi levels (p<0.001), PI (p=0.004), PD (p<0.001), gain in CAL (p=0.02) and defect fill (p= 0.024) in group A rather than group B. Conclusion: Both the groups showed a significant improvement in microbiological, clinical & radiographic parameters, but group A showed statistically significant results.

Keywords: Infra bony defects, Antimicrobial agents, Membrane, Regeneration, Bone fill.