Year : 2019

Volume : Volume 10

Issue : Issue 4

Address for correspondence :
Dr. Khushboo Desai.
drkhushboodesai@gmail.com

Abstract

Background:  Periostin, a matricellular protein, is the CNN family member protein which regulates various cancer stem cell maintenance, cancer progression and metastasis. It is also involved in cell invasion, inflammation, epithelial-mesenchymal transition, tumour growth and angiogenesis. To date, the molecular mechanisms associating periostin in relation to cancer in humans have not been fully illuminated.  Materials and Method: This study includes the identification of potential antagonist for cancer inhibition through bioinformatics technique. Around 151 phytochemicals were docked with periostin to check their effectiveness on the marker.  Results: Curcumin, luteolin and silibinin had the highest docking score, binding energy and glide gscore of the 151 phytochemicals selected to bind with periostin. Conclusion: Molecular docking of periostin with natural compounds from various plants and vegetables provide insight into high binding affinity and molecular-level interactions to combat with different cancer targets.

Keywords: Periostin, oral cancer, bioinformatics, Molecular docking.