Journal of Research and Advancement in Dentistry
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Year : 2024
Volume : Volume 15
Issue : Issue 4
Address for correspondence :
Dr. Shradha Badani
sbadani32@gmail.com
Introduction: In comparison to the casting of fresh alloys, recasting of casting alters the composition and elemental release of alloys, which may have cytotoxic effectsin the surrounding tissues. Settings and Design: Systematic review and meta-analysis. Methods: A well-structured search on the available literature as per guidelines was opted and digitally searched then results were analyzed. Atotal of 370 studies were found via PubMed, Scopus, Medline, and The Cochrane Library (Wiley) databases (PRISMA guidelines), In this review, we included in vitro studies on the effect of cytotoxicity on recasted base metal alloys. Statistical Analysis: MINORS tool was implicated for the quality assessment of the inclusion criteria applied for quasi-random trials. This scale had 10 items, and each one was evaluated as follows: 0 for not reporting the item, 1 for insufficient reporting, and 2 forsatisfactory reporting. Results: This review evaluated two studies which met the inclusion criteria to comparatively analyze the cytotoxicity between freshly prepared alloy and recasted alloy using Review Manager 5.4. The mean difference was calculated along with a 95% confidence Interval, and a significance level of P < 0.05 was considered meaningful. Incorporation of 46 samples in the fresh alloy group and 46 in the recasted alloy group were allocated. The analysis revealed a significant difference in cytotoxicity, with the recasted alloy demonstrating a higher number of viable cells (P < 0.001). To assess the statistical heterogeneity in this analysis, the I2 test was employed which indicated a high level of heterogeneity at 97%. Pre- and post-analysis was done using a fixed-effect model to interpret the treatment effects. Conclusion: This meta-analysis concluded that recasting of base metal alloys increased cell toxicity. Among the base metal alloy, the Co-Cr alloys were more adversely affected the cell viability in comparison to Ni-Cr alloys.
