Year : 2018

Volume : Volume 9

Issue : Issue 3

Address for correspondence :
Dr. K. T. Manjula.
KTManjula@gmail.com

Abstract

Background:  Genomic paradigm can be thought of as the foundation upon which a scientific structure is providing new findings and insights. In Dentistry and Orthodontics, at present, we are on the threshold of a paradigm shift that changes the fundamental and conceptual understanding of orthodontics, and with it, the traditional emphasis is on diagnosis and treatment planning. Formerly, the emphasis was on the dental and skeletal components; then the soft tissue components and now, greater attention to the genomic aspects of orthodontics is required. With the increase in knowledge of the human genome and its DNA sequence, many numbers of disease genes can now be examined using DNA analysis. Various genes attributed for craniofacial deformities are identified. The recent advances of genome-editing technologies have enabled a new hope in which the sequence of the human genome can be precisely manipulated to achieve a therapeutic effect. Fundamental concepts of genetics and applied translational research in orthodontics are opening new horizons in the procedures of gene mapping and gene therapy which provide a foundation for a new emphasis on precision orthodontics.

Keywords: Genomics, therapy, dentistry.