Year : 2018

Volume : Volume 9

Issue : Issue 2s

Address for correspondence :
Dr. Bianca B. Rodrigues.
biancabrodrigues@gmail.com

Abstract

Background: The evaluation of cytokines in the peri-miniscrew implant crevicular fluid (PMICF) has been proposed as a non-invasive means of monitoring the healthy or diseased status of peri-implant tissues. The objective of this study was to evaluate the levels of interleukin 8 (IL-8) and interleukin 4 (IL-4) around miniscrew implants during orthodontic tooth movement and to draw clinical inferences from the same.  Methodology: The study was done in retraction stage around 22 healthy titanium miniscrew implants. The samples were collected over a month time period after force application on miniscrew implants according to the following schedule: T1, T2 and T3 at 1 hour, 7th day and 21st day respectively. The PMICF samples were put through ELISA test for determining the concentration of IL-8 and IL-4. The data was analyzed using descriptive and inferential statistics that included paired t test and independent t test.  Result and interpretation: It was observed that in healthy miniscrew implants the IL- 8 levels increased from one hour to 7th day due to perimucositis and slightly decreased or remained the same from 7th to 21st day indicating that the progress of inflammation has regressed. The IL-4 levels decreased from one hour to 7th day due to perimucositis. It decreased from 7th to 21st day. This could be attributed to the persistence of inflammation through 21st day.  Conclusion:  These findings demonstrated that the levels of IL-8 and IL- 4 in PMICF could be considered in detecting the stability of miniscrew implants.

Keywords: Miniscrew implant, Peri-miniscrew implant crevicular fluid, Interleukin 8, Interleukin 4.