Journal of Research and Advancement in Dentistry
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Year : 2019
Volume : Volume 10
Issue : Issue 2
Address for correspondence :
Dr. Lohit N Naik.
drlohith.naik@gmail.com
Background: This prospective and clinical genetic study evaluates the significance of the G6R and S43K mutations in exon 2 of the paired box 9 (PAX9) gene in patients with multiple congenital missing teeth (MCMT). Materials and methods: The samples were taken from 30 Indian subjects (15 women and 15 men) with MCMT. The mean subject age was 16.85 years. Photographs and radiographs were taken. Saliva samples were collected from all subjects and sent to a genetics laboratory for single nucleotide polymorphism (SNP) analysis for evaluating G6R and S43K in exon 2 of the PAX9 gene. Results: SNP analysis of the subjects showed no transversion of either G6R or S43K in exon 2 of the PAX9 gene. Conclusions: That no sample showed transversion of either G6R or S43K in exon 2 of the PAX9 gene indicates that the phenotypic pattern of MCMT varies with race and ethnicity.
Keywords: Congenitally missing teeth, exon 2, PAX9, genetic evaluation.
