Journal of Research and Advancement in Dentistry
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Official publication of Magadh University and Kolhan University, Government of Bihar and Jharkhand, India
Year : 2015
Volume : Volume 5
Issue : Issue 1
Address for correspondence :
Dr. Koshalraj T Goyal
koshalrajgoyal@gmail.com
Background: The purpose of the study was to compare and assess the clinical efficiency of sedation by Propofol, Midazolam & Propofol-Midazolam combination on 60 subjects of either sex and age between 18-50 years. Materials and Method: This is a prospective, randomized, double blind, controlled study, which is clinically oriented with 60 subjects of either sex which needed a minor oral surgical procedure. Group A: This received Propofol bolus & continuously maintained by infusion of Propofol. Group B: This received Midazolam bolus & continuously maintained by infusion of Midazolam. Group C: This received induction by Propofol & continuously maintained by infusion of Midazolam. Ten minutes after the infusion of sedative agent/s, the local anesthetic was injected. Minor elective surgical procedures were carried out. Patient’s verbal response was determined both by the surgeon & anaesthelogist. After surgery the patient was sent to the recovery room & monitored for 2 hours, before being discharged. The patient were assessed starting with preoperative baseline vitals, then perioperative baseline vitals every ten minutes and then, postoperative baseline vitals and other parameters were recorded on a relevant data sheet Result: The anxiety score was less in group-A ( 21.5 ± 2.48, graph-1), proportion of Deep, Eye closed, rousable on mild stimulation was more in Group C as compared to Group A & Group B(graph-2). The proportion of incidence of side effects is less in Group A than other groups (graph – 3), patient satisfaction group C (4.15±0.49) and discharge score were better in Group-A ( 9.30± 0.57 graph - 4,5) and Group A was more hemodynamically stable ( graph 6,7,8) Conclusion: Propofol as a sole agent provides better anxiolysis, hemodynamic stability and reduced side effects but patient satisfaction is more in combination of propofol – midazolam combination.
Keywords: Propofol, Midazolam, Oral surgery.
