Year : 2018

Volume : Volume 9

Issue : Issue 3

Address for correspondence :
Dr. Chukka Rakesh Reddy.
ChukkaRakeshReddy@gmail.com

Abstract

Background:  The proton pump present in the cell membrane of Enterococcus Faecalis, enables it to survive in adverse conditions. Thus, the use of proton pump inhibitor (PPI) along with a calcium hydroxide Ca (OH)2-based endodontic sealer (Apexit plus) might help eradicate E. faecalis after obturation of the root canals. The aim of the present in vitro study was to evaluate the antimicrobial efficacy of PPI omeprazole in conjunction with the Apexit plus sealer against E. faecalis.  Materials and Methods: The antibacterial efficacy of 29 mg Apexit plus (group I), 2mg Omeprazole (group II), 4mg Omeprazole (group III), 29mg Apexit plus with 2mg Omeprazole (group IV), and 29mg Apexit plus with 4mg Omeprazole (group V) was evaluated against E. faecalis using the direct contact test. Sterile saline was used as a mixing medium and also served as the negative control (group VI). The number of colonies forming units were counted on agar plates, the results were statistically analysed.  Results: The results of this study showed that the antibacterial efficacy was significantly improved following the addition of omeprazole to Apexit plus (P ≤ 0.05).  Conclusion: The combination of omeprazole and Apexit plus appears to give promising results in controlling post endodontic infections.

Keywords: Antimicrobial efficacy, Apexit plus sealer, Enterococcus faecalis, Omeprazole, proton pump inhibitor.