Year : 2018

Volume : Volume 8

Issue : Issue 1

Address for correspondence :
Dr. Rimmi Daharwal.
daharwalrimmi@gmail.com

Abstract

Aim:  1. Identify And Count The Apoptotic Cells In Normal Mucosa, Oral Epithelial Dysplasia And Oral Squamous Cell Carcinoma (OSCC). 2. Compare The AI Between Normal Mucosa, Oral Epithelial Dysplasia And OSCC. 3. Compare The AI With Histological Grading Of Epithelial Dysplasia And OSCC. Materials and Methods: 50 tissue specimens were collected from patients with oral leukoplakia and OSCC. The biopsy was done and tissue was fixed at 10% buffered formalin, processed for routine paraffin sections, sections taken, stained by Hematoxylin and Eosin and examined under light microscope, using 40× objective and 10× eyepiece. Apoptotic bodies were counted in each high-power field (HPF).  Statistical Analysis: Statistical analysis was done by using one way analysis of variance to find the significance of mean apoptotic cell counted among study groups as well as among various grades in dysplasia and OSCC. Post-hoc Tukey test was used to find the pairwise significance between the groups.  Results: It was observed that AI increased from the increasing grade in dysplasia and decreased from the increasing grade in OSCC. Conclusions: The recently introduced histological parameter of AI can help to  predict the survival rate by early diagnosis and early treatment of cancer.

Keywords: Apoptotic count, oral dysplasia, oral squamous cell carcinoma.