Year : 2020

Volume : Volume 11

Issue : Issue 2s

Address for correspondence :
Dr. Mandadi Sree Sai Jeevana.
saijeevana220@gmail.com

Abstract

Background:  Several mouth rinses are assessed in the literature for the treatment of periodontal and gingival diseases.  The study's objective was to evaluate the clinical and biochemical effects of AMFRESHTM mouth rinse with REXIDINETM and placebo mouth rinse.  Materials and Methods: This single-blind, randomized, placebo-controlled clinical trial involved forty-five subjects with gingivitis, randomly divided into three groups: negative control (placebo), positive control (0.2% CHX), and test group (AMFRESH mouth rinse - 1%CHX, 0.1% Resveratrol, 0.1% Chitosan and 0.005% Curcuma longa). Mouth rinsing (adjunctive therapy was continued for 4weeks, clinical parameters (plaque index, gingival index), and biochemical measurements (reactive oxygen metabolites and total antioxidant capacity) were evaluated at baseline and four weeks.   Results: Intragroup comparison, mean values of PI, GI demonstrated significant reduction from baseline to 4 weeks, whereas ROM, TAC levels showed statistical significance in CHX and AMFRESH groups. A statistically significant difference was seen on intergroup comparison for PI, GI, ROM for all the three groups.  However, significance was noted in TAC levels of control and CHX and control and AMFRESH groups, but no significance was noted between CHX and AMFRESH groups.  Conclusion: AMFRESH mouth rinse can be considered an alternative to CHX because of its anti-inflammatory and antioxidant properties.

Keywords: Dental plaque, reactive oxygen species, lipid peroxides, antioxidants.