Year : 2020

Volume : Volume 11

Issue : Issue 3

Address for correspondence :
Dr. Ritika Agarwal.
drritikaagarwal@gmail.com

Abstract

Background:  Leukoplakia is a potentially malignant disorder (PMD) and plays a vital role in pathogenesis of oral squamous cell carcinoma. The present study was conducted to assess alteration in serum lipid profile in patients with leukoplakia. Materials & Methods: 35 cases of oral leukoplakia of both genders (Group I). Equal number of healthy subjects were also included (Group II). Lipid profile assay of the specific parameters like total cholesterol, HDL, LDL, VLDL, triglycerides were done. Results: Group I had 28 males and 7 females and group II had 29 males and 6 females. Common site was gingiva in 8%, palate in 5%, tongue in12%, buccal mucosa in 45% and lip commissure in 30%. The mean triglyceride in group I was 80.2 mg/dl and in group II was 94.6 mg/dl, total cholesterol was 124.6 mg/dl and in group I and 156.2 mg/dl, HDL was 32.4 mg/dl and 46.2 mg/dl in group I and II respectively, LDL was 106.2 mg/dl and 96.4 mg/dl in group I and II respectively, VLDL was 20.4 mg/dl in group I and18.2 mg/dl in group II. The difference was significant (P< 0.05). Conclusion: Alterations in the plasma lipid profile patterns were significant. There was higher level of lipid in leukoplakia than healthy subjects.

Keywords: Lipid profile, Leukoplakia, Potentially malignant disorder.