Year : 2021

Volume : Volume 12

Issue : Issue 3

Address for correspondence :
Dr. Suryakanth Malgika
drmalgikarsuryakanth@gmail.com

Abstract

Background: The aim of the study was to correlate and compare clinically and radiographically the efficacy of recombinant human plateletderived growth factor (rhPDGF) as an adjunct to β-tricalcium phosphate (β-TCP) and chorion membrane grafting versus β-TCP and chorion membrane alone in the treatment Grade II furcation defects in chronic periodontitis. Materials and Methods: Thirty sites (15 in each Group) with Grade II furcation defects were randomly assigned and treated as Group I (Control) furcation defect filled with β-TCP followed by placement of chorion membrane and Group II (Test) furcation defect filled with rhPDGF-BB + β-TCP followed by placement of chorion membrane. Clinical parameters (PI, GI, PPD, and RAL) and radiographic defect fill were recorded at Baseline, 1 month, 3 months, and 6 months. Results: Among the outcome measures, it resulted in significantly higher area under the curve, relative attachment level gain at 0–6 months (P < 0.05) and greater reduction in probing depth at the 3rd and the 6th month in Group II (rhPDGF + β-TCP + chorion membrane) than Group I (β-TCP + chorion membrane). Conclusion: Mean percentage defect fill was significantly greater in test sites as compared with control sites at 3 and 6 months (P < 0.05). Both groups demonstrated potential in enhancing periodontal regeneration; however, on comparison between the two groups, the results obtained by rhPDGF + β-TCP+ chorion membrane were significantly better with respect to both clinical and radiographic parameters.

Keywords: Recombinant platelet derived growth factor, Chorion membrane, Beta-tricalcium phosphate, Furcation defects, Periodontal regeneration.