Year : 2020

Volume : Volume 11

Issue : Issue 2

Address for correspondence :
Dr. Shouvik Mandal
shouvik.dr@gmail.com

Abstract

Background:  Oral health may be indicative of systemic health and vice versa. Genetic make of an individual influence both the oral and systemic health as well as the phenotypic features of individuals. Therefore, obtaining genetic information of an individual enable a clinician to better understand the problem for clinical management and also guide them on an occasion of a hereditary pattern of clinical condition. A strong genetic correlation is seen to be associated to the inflammatory periodontal disease (PD) among patients and their family initiating researchers to search for information regarding the same. The present report describes a family with periodontal disease through three generations. A routine somatic karyotyping in peripheral blood had detected a pericentric inversion in one chromosome 9 i.e., inv (9) in members of the two generations, which was speculated to be associated with periodontal disease present in the family. However, the third member with PD didn’t have the inversion, though the likelihood of genetic recombination with the inv (9) during meiotic cell division exists for gametogenesis. Inv (9) is associated with a number of clinical conditions; however, it is not considered as a marker of clinical expression. The present case with association of PD and inv (9), and hereditary condition of PD might attract molecular researchers for deciphering the genetic condition of hereditary and/or de novo PD, which might throw some light on genetic understanding of dental management clinically.

Keywords: Periodontal disease, pericentric inversion, chromosome 9, copy number variation.